EFFECTS OF CLEAROGEN ACNE LOTION ON TESTOSTERONE METABOLISM IN RECONSTRUCTED HUMAN EPIDERMIS
PROPOSAL N°: AD070315C-2 STUDy N°: AD070315A DATE: OCTOBER 18TH, 2007
Franck JUCHAUX Study director October 18th, 2007
TABLES 1 AND 2
After 24h of culture, the rate of testosterone metabolism was very high.
Dihydrotestosterone (DHT) was clearly identified in the steroid profile. DHT was the major metabolite in the control epidermis. After 24h, about 74% of the deposited testosterone was converted into DHT.
Other important metabolites were androstane-diols (e) and 4-androstene- 3,17-dione (b).
Effects of finasteride:
Finasteride at 10-5 M strongly inhibited the transformation of testosterone into DHT (67% inhibition compared to the control). Furthermore, as expected, finasteride decreased the amount of androstane-diols (e) and induced a strong accumulation of 4-androstene-3,17-dione (b) (Figure 1).
Effects of dutasteride:
Dutasteride at 10-6 M and 10-5 M strongly inhibited dose dependently the transformation of testosterone into DHT (respectively 80% and 86% of inhibition of the DHT production compared to the control). Furthermore, as expected, dutasteride decreased the amount of androstane-diols (e) and induced a strong accumulation of 4-androstene-3,17-dione (b) (Figure 1).
Effects of Clearogen Acne Lotion:
Clearogen Acne Lotion (5 mg/cm2) reduced the transformation of testosterone into DHT (49% of inhibition of the DHT production compared to the control) and of DHT into androstane-diols (e). Surprisingly the accumulation of 4-androstene-3,17-dione (b) was not visible.
To conclude, Clearogen Acne Lotion clearly decreased the production of DHT and therefore could be used to treat acne.
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